Isolation of targeting nanobodies against co-opted tumor vasculature
نویسندگان
چکیده
منابع مشابه
There will be blood: targeting tumor vasculature.
Wherever there is cancer, there will be blood and blood vessels to support tumor growth. While the majority of anticancer drugs are designed to directly kill tumor cells, recent strategies are focusing on drugs that indirectly kill cancer cells by targeting the tumor microenvironment and tumor vasculature. This strategy gained a significant boost with the approval of the angiogenesis inhibitor ...
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متن کاملComplexity of tumor vasculature and molecular targeting therapies.
Malignant solid tumors require blood supply for their uncontrollable progression. Angiogenic blood vessels generally sprout from preexisting vascular cells. In addition, various types of precursor cells also participate in tumor neovascularization. They include endothelial progenitor cells, hematopoietic stem cells and mesenchymal stem cells that are stimulated and attracted into tumor lesion, ...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2009
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.2009.107